Test your hereditary cancer risk with GeneMate®.
By understanding your hereditary cancer risk, you and your care provider can develop a plan to significantly reduce your risk or enable early detection through more frequent screening. GeneMate® provides a comprehensive risk assessment through the combination of genetic testing and an assessment of family cancer history.Order
Lifetime cancer risk
How common is cancer?
Roughly one third of the population will develop cancer in their lifetime, and 5-10% of all cancer is hereditary. Still, 97% of those at risk for hereditary cancer remain unidentified.
Hereditary cancer may be due to one underlying genetic variant – also called a mutation – or a combination of several variants and environmental factors.
Certain cancers are more strongly linked to hereditary factors than others. Colorectal cancer is the third most common cancer worldwide, and as much as one third of all cases are thought to be hereditary.
Know your risk with GeneMate®
Through GeneMate® you can identify whether you carry an increased risk for hereditary cancer. GeneMate® combines genetic testing with a review of your family’s cancer history for a comprehensive assessment.
An assessment of the DNA in your saliva reveals whether you carry a genetic variant (mutation) that increases your risk of cancer.
Your family’s cancer history is reviewed for clinical indicators of hereditary cancer.
Select the test that suits your needs
For individuals who want to test their hereditary risk for cancer.
For women who want to test their hereditary breast cancer risk. A family history of breast, ovarian, prostate, and/or pancreatic cancer increases the likelihood of inherited risk.
For men who want to test their hereditary prostate cancer risk. A family history of breast, ovarian, prostate, and/or pancreatic cancer increases the likelihood of inherited risk.
For individuals who want to test their risk for hereditary colorectal cancer or Lynch Syndrome. A family history of colorectal, uterine, ovarian, small intestine, stomach, and/or urinary tract cancer increases the likelihood of inherited risk.
GeneMate® Breast +
For women who want a complete assessment of their hereditary breast cancer risk, including 4 genes that less frequently carry pathogenic variants.
GeneMate® Prostate & Colon
For men who want to test their hereditary risk for both colorectal cancer and prostate cancer.
GeneMate® Breast, Gyn & Colon
For women who want to test their hereditary risk for breast, ovarian, uterine, and colorectal cancer.
Is GeneMate® right for me?
GeneMate® is intended for adults 18 years of age or older who would like to know if they have an increased risk for hereditary cancer. Please note that pathogenic variants are rare in the general population. The probability is increased, however, if any of the following are true:
- If you or a close relative1 have been diagnosed with cancer at a young age, such as breast cancer before 40. What is considered young varies by cancer type.
- If you or a close relative have had several cancer diagnoses.
- If you or a close relative have had a rare cancer diagnosis.
- If several close relatives have had the same or related cancer diagnoses. Colorectal cancer and uterine cancer, for example, are related cancer types.
Research shows, however, that many individuals with pathogenic variants do not meet these criteria.
Still wondering if GeneMate® is right for you? Get in touch at firstname.lastname@example.org and we’ll be happy to answer your questions.
1 Close relatives include: parents, siblings, half siblings, children, grandchildren, grandparents, aunts, uncles, nieces, and nephews.
How does GeneMate® work?
Order your GeneMate® test online.Order
A sample collection kit will be delivered directly to your mailbox for at-home saliva collection.
Activate your test online and return your sample in the same box it came in.
Our clinical team is always available for consultation.
Increased risk? We’ll refer you to the appropriate care provider.
Your hereditary risk lies in your DNA
While genetic variants are rare, they say a lot about an individual’s risk of developing certain cancers. A woman with a pathogenic variant in the gene BRCA1, for example, has a 50-80% risk of developing breast cancer, while the average woman has a risk of only 10%.
Breast Cancer Risk
Ovarian Cancer Risk
Get to know your DNA with GeneMate®
Analytical validation of the GeneMate® test has shown >99% sensitivity, >99% specificity, and >99.9% reproducibility. In other words, GeneMate® identifies existing gene variants at an exceedingly high rate (sensitivity), while maintaining minimal risk for false positives (specificity).
The GeneMate® panel covers all cancer types that are known to have a clinically significant hereditary component. Targeted services (such as GeneMate® Breast) cover a smaller subset of cancer types.
The GeneMate® test’s 41-gene panel has been thoughtfully developed with regard to clinical relevance and actionability. Genes have been selected in accordance with Swedish and American clinical care guidelines2. Targeted services (such as GeneMate® Breast) analyze a subset of these genes for one to a few cancer types. The genes analyzed for each services are shown above.
Those who meet certain clinical criteria qualify for evaluation via the public healthcare system at one of Sweden’s oncogenetic clinics in Lund, Gothenburg, Linköping, Stockholm, Uppsala, or Umeå. Research shows, however, that many carriers (i.e. those with pathogenic genetic variants) cannot be identified using today’s clinical criteria. Those who do meet the criteria may encounter long wait times or a series of hospital visits. GeneMate® is criteria-free, utilizes at-home sample collection, and has a turnaround time of 4-6 weeks. Genetic counseling is offered by phone. Quite simply, we meet you where you are.